PD is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) 1. Parkinson disease (PD) can be regarded as an age-dependent neurodegenerative disorder affecting movement abilities. The present study, therefore, for the first time, revealed two candidate lncRNAs as the biomarkers in the PD patients. In addition, this study demonstrated that linc00938 directly sponged hsa-miR-30c-5p. While, the Linc00938, LRRK2 and ATP13A2 expression were up-regulated in the PBMC of the PD patients, in comparison to the controls. The results of the expression profiles of six nodes of the two ceRNA networks shown that linc01128, hsa-miR-24-3p and hsa-miR-30c-5p expression were significantly downregulated. Further, this study investigated the direct interaction between one of the lncRNAs and target miRNA by using the dual luciferase assay. Then, we compared the expression of these RNAs in both early and late stages of PD with the controls to determine if their expression could be related to the severity of disease. We evaluated the expression profiles of six nodes of two regulatory networks in the PBMCs which had been got from 38 PD patients and 20 healthy individuals by qRT-PCR. The purpose of this research was to introduce two novel lncRNAs as the biomarker of PD diagnosis and treatment. Parkinson disease (PD) is the second most common neurodegenerative disease the evidence suggests that lncRNAs and miRNAs play an important role in regulating the PD-related genes.
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